FOR, a Novel Orphan Nuclear Receptor Related to Farnesoid X Receptor

CXR , a novel xenobiotic - sensing orphan nuclear receptor is related to both mammalian pregnane X receptor ( PXR ) and constitutive androstane receptor ( CAR )

Bile Acid Nuclear Receptor Farnesoid X Receptor: Therapeutic Target for Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) is one of the causes of fatty liver, occurring when fat is accumulated in the liver without alcohol consumption. NAFLD is the most common liver disorder in advanced countries. NAFLD is a spectrum of pathology involving hepatic steatosis with/without inflammation and nonalcoholic steatohepatitis with accumulation of hepatocyte damage and hepatic fibrosis....

The Farnesoid X Receptor: Good for BAD

Diarrhea is a feature of several chronic intestinal disorders that are associated with increased delivery of bile acids into the colon. Although the prevalence of bile acid diarrhea is high, affecting approximately 1% of the adult population, current therapies often are unsatisfactory. By virtue of its capacity to inhibit colonic epithelial fluid secretion and to down-regulate hepatic bile acid...

Transcriptional Activities of the Orphan Nuclear Receptor ERRa (Estrogen Receptor-Related Receptor-a)

Estrogen receptor-related receptor a (ERRa) is an orphan nuclear receptor closely related to the estrogen receptor (ER), whose expression covers various stages of embryonic development and persists in certain adult tissues. We show that ERRa binds as a homodimer on a specific target sequence, the SFRE (SF-1 response element), already known to respond to the orphan nuclear receptor SF-1. Target ...

Coactivators for the Orphan Nuclear Receptor RORa

A mutation in the nuclear orphan receptor RORa results in a severe impairment of cerebellar development by unknown mechanisms. We have shown previously that RORa contains a strong constitutive activation domain in its C terminus. We therefore searched for mammalian RORa coactivators using the minimal activation domain as bait in a two-hybrid screen. Several known and putative coactivators were ...